Vitamin D immunoregulation through dendritic cells

Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions.

OBJECTIVE To determine whether the administration of an active form of vitamin D(3) (calcitriol) could prevent atherosclerosis through anti-inflammatory actions. METHODS AND RESULTS Recent clinical studies have shown that lack of vitamin D(3) is a risk factor for cardiovascular events. Oral calcitriol administration decreased atherosclerotic lesions, macrophage accumulation, and CD4(+) T-cell...

Transcriptional Profiling of T Cells Identifies a Role for Vitamin D in the Immunoregulation of the V 9V 2 Response to Phosphate-Containing Ligands

Vitamin D3 Reduction in Individuals Exposed to Sulfur Mustard

Background: Inflammatory responses in individuals exposed to sulfur mustard occur in some organs such as lung, skin and eyes. These organs manifest overreaction in cellular and humoral immune responses. Over a long period, the immune responses often continues toward chronic inflammatory processes with some interventions. Obviously some elements have been deregulated. Therefore, this study evalu...

In Vivo Effects of Calcitriol on Phenotypic and Functional Properties of Dendritic Cells

Background: Dendritic cells (DCs) play a central role in the initiation and expansion of T cell mediated immune responses with potential immunotherapy application. The compounds which have the ability to induce immunomodulatory effects on DCs may be employed for the treatment of immunopathologic conditions such as autoimmune diseases. Objective: The aim of this study was to investigate the in v...

Activation through Cannabinoid Receptors 1 and 2 on Dendritic Cells Triggers NF- B-Dependent Apoptosis: Novel Role for Endogenous and Exogenous Cannabinoids in Immunoregulation